|Calculated MW||12.5 kDa (111 aa, 369-478 aa), confirmed by MALDI-TOF.|
|Other Names||BMP-3b, BMP3B, BIP, Growth differentiation factor 10|
|Sequence||MQWDEPRVCS RRYLKVDFAD IGWNEWIISP KSFDAYYCAG ACEFPMPKIV RPSNHATIQS IVRAVGIIPG IPEPCCVPDK MNSLGVLFLD ENRNVVLKVY PNMSVDTCAC R|
|Storage||-80°C; 1 mg/ml in 10 mM sodium citrate (pH 3.5) containing 10% glycerol|
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GDF10 (Growth differentiation factor 10) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It is expressed in femur, brain, lung, skeletal, muscle, pancreas and testis, and it plays a role in head formation and may have multiple roles in skeletal morphogenesis. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Recombinant GDF10 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Hino J.,et al.Biochem. Biophys. Res. Commun. 223:304-310(1996).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Cunningham N.S.,et al.Growth Factors 12:99-109(1995).
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