|Calculated MW||13.1 kDa (117 aa, 23-116 aa + His tag), confirmed by MALDI-TOF.|
|Other Names||CD3g molecule, gamma (CD3-TCR complex), CD3-GAMMA, T3G|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATIS|
|Storage||-80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. Recombinant human CD3G protein, fused to His-tag at N-terminus, was expressed in E.coli.
Krissansen G.W.,et al.EMBO J. 5:1799-1808(1986).
Tunnacliffe A.,et al.EMBO J. 6:2953-2957(1987).
Alexander D.,et al.Eur. J. Biochem. 181:55-65(1989).
Davies A.A.,et al.J. Biol. Chem. 262:10918-10921(1987).
Letourneur F.,et al.Cell 69:1143-1157(1992).
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