|Calculated MW||13.1 kDa (117 aa, 23-116 aa + His tag), confirmed by MALDI-TOF.|
|Other Names||CD3g molecule, gamma (CD3-TCR complex), CD3-GAMMA, T3G|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATIS|
|Storage||-80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. Recombinant human CD3G protein, fused to His-tag at N-terminus, was expressed in E.coli.
Krissansen G.W.,et al.EMBO J. 5:1799-1808(1986).
Tunnacliffe A.,et al.EMBO J. 6:2953-2957(1987).
Alexander D.,et al.Eur. J. Biochem. 181:55-65(1989).
Davies A.A.,et al.J. Biol. Chem. 262:10918-10921(1987).
Letourneur F.,et al.Cell 69:1143-1157(1992).
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