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CD46, human recombinant protein

Membrane cofactor protein isoform 14, AHUS2, MCP, MIC10, TLX, TRA2.10

     
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Product info
Primary Accession P15529
Concentration 1
Calculated MW 33.8 kDa (302 aa, 35-313 aa + His tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 4179
Gene Symbol CD46
Other Names Membrane cofactor protein isoform 14, AHUS2, MCP, MIC10, TLX, TRA2.10
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥85%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LD
Target/Specificity CD46
Format Liquid
Storage -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.
Citations (0)

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Background

Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Lublin D.M.,et al.J. Exp. Med. 168:181-194(1988).
Purcell D.F.,et al.Immunogenetics 33:335-344(1991).
Post T.W.,et al.J. Exp. Med. 174:93-102(1991).
Cervoni F.,et al.Mol. Reprod. Dev. 34:107-113(1993).
Hara T.,et al.Immunology 93:546-555(1998).

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$ 295.00
Cat# PBV10938r
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