CD46, human recombinant protein
Membrane cofactor protein isoform 14, AHUS2, MCP, MIC10, TLX, TRA2.10
|Calculated MW||33.8 kDa (302 aa, 35-313 aa + His tag), confirmed by MALDI-TOF.|
|Other Names||Membrane cofactor protein isoform 14, AHUS2, MCP, MIC10, TLX, TRA2.10|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LD|
|Storage||-80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Lublin D.M.,et al.J. Exp. Med. 168:181-194(1988).
Purcell D.F.,et al.Immunogenetics 33:335-344(1991).
Post T.W.,et al.J. Exp. Med. 174:93-102(1991).
Cervoni F.,et al.Mol. Reprod. Dev. 34:107-113(1993).
Hara T.,et al.Immunology 93:546-555(1998).
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