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CD5, human recombinant protein

T-cell surface glycoprotein CD5, LEU1, T1

     
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  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product info
Primary Accession P06127
Concentration 1
Calculated MW 41.0 kDa (371 aa, 25-372 aa + His tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 921
Gene Symbol CD5
Other Names T-cell surface glycoprotein CD5, LEU1, T1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥80%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSRLSWYDP DFQARLTRSN SKCQGQLEVY LKDGWHMVCS QSWGRSSKQW EDPSQASKVC QRLNCGVPLS LGPFLVTYTP QSSIICYGQL GSFSNCSHSR NDMCHSLGLT CLEPQKTTPP TTRPPPTTTP EPTAPPRLQL VAQSGGQHCA GVVEFYSGSL GGTISYEAQD KTQDLENFLC NNLQCGSFLK HLPETEAGRA QDPGEPREHQ PLPIQWKIQN SSCTSLEHCF RKIKPQKSGR VLALLCSGFQ PKVQSRLVGG SSICEGTVEV RQGAQWAALC DSSSARSSLR WEEVCREQQC GSVNSYRVLD AGDPTSRGLF CPHQKLSQCH ELWERNSYCK KVFVTCQDPN P
Target/Specificity CD5
Format Liquid
Storage -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Citations (0)

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Background

CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis. Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in E.coli.

References

Jones N.H.,et al.Nature 323:346-349(1986).
Calvo J.,et al.Tissue Antigens 47:257-261(1996).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 275.00
Cat# PBV10939r
Size:
Quantity:
(40 western blots)
Availability: 5-7days
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