CD74, human recombinant protein
HLA class II histocompatibility antigen gamma chain isoform b, DHLAG, HLADG, Ia-GAMMA, II
|Calculated MW||20.6 kDa (183 aa, 73-232 aa + His tag), confirmed by MALDI-TOF.|
|Other Names||HLA class II histocompatibility antigen gamma chain isoform b, DHLAG, HLADG, Ia-GAMMA, II|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSQQQGRLD KLTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP MGALPQGPMQ NATKYGNMTE DHVMHLLQNA DPLKVYPPLK GSFPENLRHL KNTMETIDWK VFESWMHHWL LFEMSRHSLE QKPTDAPPKE SLELEDPSSG LGVTKQDLGP VPM|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 1 mM DTT and 30% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
HLA class II histocompatibility antigen gamma chain isoform b, also known as CD74, is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant human CD74 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Claesson L.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983).
Strubin M.,et al.EMBO J. 3:869-872(1984).
Kudo J.,et al.Nucleic Acids Res. 13:8827-8841(1985).
O'Sullivan D.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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