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CD8B, human recombinant protein
T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEU2, LY3, LYT3, P37
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10966 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 19.2 kDa (172 aa, 22-170 aa + His tag), confirmed by MALDI-TOF. |
| Gene ID | 926 |
|---|---|
| Gene Symbol | CD8B |
| Other Names | T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEU2, LY3, LYT3, P37 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥80% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP |
| Target/Specificity | CD8B |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Recombinant human CD8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
References
Norment A.M.,et al.EMBO J. 7:3433-3439(1988).
Disanto J.P.,et al.EMBO J. 7:3465-3470(1988).
Shiue L.,et al.J. Exp. Med. 168:1993-2005(1988).
Nakayama K.,et al.J. Immunol. 148:1919-1927(1992).
Hillier L.W.,et al.Nature 434:724-731(2005).
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