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CD8B, human recombinant protein

T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEU2, LY3, LYT3, P37

     
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Product info
Primary Accession P10966
Concentration 0.5
Calculated MW 19.2 kDa (172 aa, 22-170 aa + His tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 926
Gene Symbol CD8B
Other Names T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEU2, LY3, LYT3, P37
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥80%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP
Target/Specificity CD8B
Format Liquid
Storage -80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Citations (0)

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Background

CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Recombinant human CD8B protein, fused to His-tag at N-terminus, was expressed in E.coli.

References

Norment A.M.,et al.EMBO J. 7:3433-3439(1988).
Disanto J.P.,et al.EMBO J. 7:3465-3470(1988).
Shiue L.,et al.J. Exp. Med. 168:1993-2005(1988).
Nakayama K.,et al.J. Immunol. 148:1919-1927(1992).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 295.00
Cat# PBV10944r-100
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