IRF1, human recombinant protein
Interferon regulatory factor-1, MAR
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P10914 |
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Concentration | 1 |
Calculated MW | 15 kDa (134 aa, 1-114 aa + His tag), confirmed by MALDI-TOF. |
Gene ID | 3659 |
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Gene Symbol | IRF1 |
Other Names | Interferon regulatory factor-1, MAR |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥90% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Sequence | MGSSHHHHHH SSGLVPRGSH MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPP |
Target/Specificity | IRF1 |
Format | Liquid |
Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IRF1, Interferon regulatory factor 1, is a member of the interferon regulatory transcription factor (IRF) family which regulates gene expression critical to immune response, hematopoiesis and proliferation. IRF-1 is a transcriptional activator for IFN-alpha, IFN-beta, and IFN-gamma stimulated genes. IRF1 is also a tumor suppressor transcription factor inducing apoptosis of tumorigenic cell lines. Recombinant human IRF1 was expressed in E.coli and purified by using conventional chromatography techniques.
References
Maruyama M.,et al.Nucleic Acids Res. 17:3292-3292(1989).
Miyamoto M.,et al.Cell 54:903-913(1988).
Cha Y.,et al.DNA Cell Biol. 11:605-611(1992).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Willman C.L.,et al.Science 259:968-971(1993).
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