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IRF3, human recombinant protein
Interferon regulatory factor-3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14653 |
|---|---|
| Concentration | 1 |
| Calculated MW | 13 kDa (112 aa, 1-112 aa), confirmed by MALDI-TOF. |
| Gene ID | 3661 |
|---|---|
| Gene Symbol | IRF3 |
| Other Names | Interferon regulatory factor-3 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS |
| Target/Specificity | IRF3 |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml in Phosphate-buffered saline (pH 7.4). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. Recombinant human IRF3 was expressed in E.coli and purified by using conventional chromatography techniques.
References
Au W.W.-C.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:11657-11661(1995).
Tabata Y.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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