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IL18BP, human recombinant protein

Interleukin-18-binding protein, IL18BPa

     
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Product info
Primary Accession O95998
Concentration 1
Calculated MW 20 kDa (187 aa, 31-194 aa + His Tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 10068
Gene Symbol IL18BP
Other Names Interleukin-18-binding protein, IL18BPa
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG
Target/Specificity IL18BP
Format Liquid
Storage -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Citations (0)

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Background

IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.

References

Novick D.,et al.Immunity 10:127-136(1999).
Aizawa Y.,et al.FEBS Lett. 445:338-342(1999).
Xiang Y.,et al.Virology 257:297-302(1999).
Kim S.-H.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:1190-1195(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 295.00
Cat# PBV10948r
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