|Calculated MW||20 kDa (187 aa, 31-194 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Interleukin-18-binding protein, IL18BPa|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG|
|Storage||-80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.
Novick D.,et al.Immunity 10:127-136(1999).
Aizawa Y.,et al.FEBS Lett. 445:338-342(1999).
Xiang Y.,et al.Virology 257:297-302(1999).
Kim S.-H.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:1190-1195(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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