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RAET1E, human recombinant protein
NKG2D ligand 4, bA350J20.7, LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TD07 |
|---|---|
| Concentration | 1 |
| Calculated MW | 24.9 kDa (219 aa, 31-225 aa + His Tag), confirmed by MALDI-TOF. |
| Gene ID | 135250 |
|---|---|
| Gene Symbol | RAET1E |
| Other Names | NKG2D ligand 4, bA350J20.7, LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSMHSLCFN FTIKSLSRPG QPWCEAQVFL NKNLFLQYNS DNNMVKPLGL LGKKVYATST WGELTQTLGE VGRDLRMLLC DIKPQIKTSD PSTLQVEMFC QREAERCTGA SWQFATNGEK SLLFDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSK GDCDHWLREF LGHWEAMPEP TVSPVNASDI HWSSSSLPD GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S |
| Target/Specificity | RAET1E |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 0.4 M Urea. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RAET1E belongs to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. RAET1E and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human RAET1E protein, fused to His-tag at N-terminus, was expressed in E.coli.
References
Conejo-Garcia J.-R.,et al.Cancer Biol. Ther. 2:446-451(2003).
Chalupny N.J.,et al.Biochem. Biophys. Res. Commun. 305:129-135(2003).
Bacon L.,et al.J. Immunol. 173:1078-1084(2004).
Cao W.,et al.J. Biol. Chem. 282:18922-18928(2007).
Lanier L.L.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
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