SFTPD, human recombinant protein
Pulmonary surfactant-associated protein D precursor, COLEC7, PSP-D, SFTP4, SP-D
|Calculated MW||18.9 kDa (175 aa, 224-375 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Pulmonary surfactant-associated protein D precursor, COLEC7, PSP-D, SFTP4, SP-D|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSVASLRQQ VEALQGQVQH LQAAFSQYKK VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW NDRACGEKRL VVCEF|
|Storage||-80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 0.4 M Urea.|
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SFTPD, as known as Surfactant pulmonary-associated protein D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. It is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Recombinant human SFTPD protein, fused to His-tag at N-terminus, was expressed in E.coli.
Lu J.,et al.Biochem. J. 284:795-802(1992).
Crouch E.,et al.J. Biol. Chem. 268:2976-2983(1993).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Crouch E.,et al.Am. J. Pathol. 142:241-248(1993).
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