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TNFSF8, human recombinant protein

tumor necrosis factor ligand superfamily member 8, CD153, CD30L, CD30LG

     
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Product info
Primary Accession P32971 
Concentration 0.5
Calculated MW 22 kDa (195 aa, 63-234 aa + His Tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 944
Gene Symbol TNFSF8
Other Names tumor necrosis factor ligand superfamily member 8, CD153, CD30L, CD30LG
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥80%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSQRTDSIP NSPDNVPLKG GNCSEDLLCI LKRAPFKKSW AYLQVAKHLN KTKLSWNKDG ILHGVRYQDG NLVIQFPGLY FIICQLQFLV QCPNNSVDLK LELLINKHIK KQALVTVCES GMQTKHVYQN LSQFLLDYLQ VNTTISVNVD TFQYIDTSTF PLENVLSIFL YSNSD
Target/Specificity TNFSF8
Format Liquid
Storage -80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol and 0.4 M Urea.
Citations (0)

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Background

TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Recombinant human TNFSF8 protein, fused to His-tag at N-terminus, was expressed in E.coli.

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$ 275.00
Cat# PBV10955r
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