PDCD1LG2, human recombinant protein
Programmed cell death 1 ligand 2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2
|Calculated MW||22.8 kDa (204 aa, 20-200 aa + His Tag), confirmed by MALDI-TOF. (MW on SDS-PAGE shifts up)|
|Other Names||Programmed cell death 1 ligand 2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSLFTVTVP KELYIIEHGS NVTLECNFDT GSHVNLGAIT ASLQKVENDT SPHRERATLL EEQLPLGKAS FHIPQVQVRD EGQYQCIIIY GVAWDYKYLT LKVKASYRKI NTHILKVPET DEVELTCQAT GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVR|
|Storage||-80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 0.4 M Urea.|
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Provided below are standard protocols that you may find useful for product applications.
Programmed cell death 1 ligand 2, also known as PDCD1LG2, is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Recombinant human PDCD1LG2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Tseng S.-Y.,et al.J. Exp. Med. 193:839-846(2001).
Latchman Y.,et al.Nat. Immunol. 2:261-268(2001).
He X.-H.,et al.Acta Biochim. Biophys. Sin. 36:284-289(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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