CD244, human recombinant protein
CD244 molecule, natural killer cell receptor 2B4, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
|Calculated MW||25.5 kDa (230 aa, 19-224 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||CD244 molecule, natural killer cell receptor 2B4, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSH GKGCQG SADHVVSISG VPLQLQPNSI QTKVDSIAWK KLLPSQNGFH HILKWENGSL PSNTSNDRFS FIVKNLSLLI KAAQQQDSGL YCLEVTSISG KVQTATFQVF VFDKVEKPRL QGQGKILDRG RCQVALSCLV SRDGNVSYAW YRGSKLIQTA GNLTYLDEEV DINGTHTYTC NVSNPVSWES HTLNLTQDCQ NAHQEFRFWP|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea.|
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Provided below are standard protocols that you may find useful for product applications.
CD244 (Natural Killer Cell Receptor 2B4), also known as Cluster of Differentiation 244, contains 2 Ig-like (immunoglobulin-like) domains. A role for the subtypes of CD2 Ig superfamily receptors has been recently demonstrated in eosinophilic inflammation in experimental asthma and atopic asthmatics. Functions of CD244 molecules are in eosinophil adhesion and chemotaxis, and correlated the results to the pathophysiology of allergic rhinitis (AR). The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Recombinant human CD244 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Nakajima H.,et al.Eur. J. Immunol. 29:1676-1683(1999).
Kubin M.Z.,et al.Eur. J. Immunol. 29:3466-3477(1999).
Tangye S.G.,et al.J. Immunol. 162:6981-6985(1999).
Boles K.S.,et al.Tissue Antigens 54:27-34(1999).
Kumaresan P.R.,et al.Immunogenetics 51:987-992(2000).
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