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CD3E, human recombinant protein
T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07766 |
|---|---|
| Concentration | 1 |
| Calculated MW | 14.1 kDa (127 aa, 23-126 aa + His Tag), confirmed by MALDI-TOF. |
| Gene ID | 916 |
|---|---|
| Gene Symbol | CD3E |
| Other Names | T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMD |
| Target/Specificity | CD3E |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD3E is the CD3-epsilonpolypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. Recombinant human CD3E protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
References
Gold D.P.,et al.Nature 321:431-434(1986).
Terhorst C.,et al.Submitted (JAN-1987) to the EMBL/GenBank/DDBJ databases.
Clevers H.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:8156-8160(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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