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CD3E, human recombinant protein

T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE

     
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Product info
Primary Accession P07766
Concentration 1
Calculated MW 14.1 kDa (127 aa, 23-126 aa + His Tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 916
Gene Symbol CD3E
Other Names T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMD
Target/Specificity CD3E
Format Liquid
Storage -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, and 10% glycerol.
Citations (0)

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Background

CD3E is the CD3-epsilonpolypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. Recombinant human CD3E protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Gold D.P.,et al.Nature 321:431-434(1986).
Terhorst C.,et al.Submitted (JAN-1987) to the EMBL/GenBank/DDBJ databases.
Clevers H.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:8156-8160(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
Cat# PBV10966r
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