CXCL17, human recombinant protein
Chemokine (C-X-C motif) ligand 17, Dcip1, DMC, MGC138300, UNQ473, VCC-1, VCC1
|Calculated MW||13.7 kDa (119 aa, 22-119 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Chemokine (C-X-C motif) ligand 17, Dcip1, DMC, MGC138300, UNQ473, VCC-1, VCC1|
|Sequence||MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL|
|Storage||-80°C; 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
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Chemokine (C-X-C motif) ligand 17, also known as CXCL17, is a small cytokine belonging to the CXC chemokine family. CXCL17 is a 119 amino acid secreted protein that plays a role in angiogenesis. CXCL17 is expressed in skeletal muscle, trachea, lung, intestine and stomach, and is upregulated in duodenal mucosa of patients with acute cholera, as well as breast tumors. CXCL17 is considered a housekeeping chemokine for the movement of immature dendritic cells and non-activated blood monocytes into tissues, and is thought to be involved in the innate immune response. Recombinant human CXCL17 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Weinstein E.J.,et al.Biochem. Biophys. Res. Commun. 350:74-81(2006).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
Pisabarro M.T.,et al.J. Immunol. 176:2069-2073(2006).
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