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ICAM2, human recombinant protein
Intercellular adhesion molecule 2, CD102
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P13598 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 24.8 kDa (225 aa, 22-223 aa + His Tag), confirmed by MALDI-TOF. |
| Gene ID | 3384 |
|---|---|
| Gene Symbol | ICAM2 |
| Other Names | Intercellular adhesion molecule 2, CD102 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSSDEKVFE VHVRPKKLAV EPKGSLEVNC STTCNQPEVG GLETSLDKIL LDEQAQWKHY LVSNISHDTV LQCHFTCSGK QESMNSNVSV YQPPRQVILT LQPTLVAVGK SFTIECRVPT VEPLDSLTLF LFRGNETLHY ETFGKAAPAP QEATATFNST ADREDGHRNF SCLAVLDLMS RGGNIFHKHS APKMLEIYEP VSDSQ |
| Target/Specificity | ICAM2 |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Recombinant human ICAM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
References
Staunton D.E.,et al.Nature 339:61-64(1989).
Garcia-Aguilar J.,et al.Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases.
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
Wollscheid B.,et al.Nat. Biotechnol. 27:378-386(2009).
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