KLRG1, human recombinant protein
Killer cell lectin-like receptor subfamily G member 1, 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LI
|Calculated MW||17 kDa (153 aa, 60-189 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Killer cell lectin-like receptor subfamily G member 1, 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSLCQGSNY STCASCPSCP DRWMKYGNHC YYFSVEEKDW NSSLEFCLAR DSHLLVITDN QEMSLLQVFL SEAFCWIGLR NNSGWRWEDG SPLNFSRISS NSFVQTCGAI NKNGLQASSC EVPLHWVCKK VRL|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
KLRG1 belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. Recombinant human KLRG1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Lamers M.B.A.C.,et al.Biochim. Biophys. Acta 1399:209-212(1998).
Butcher S.,et al.Eur. J. Immunol. 28:3755-3762(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ibegbu C.C.,et al.J. Immunol. 174:6088-6094(2005).
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