KLRK1, human recombinant protein
NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D
|Calculated MW||19.2 kDa (168 aa, 73-216 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSMIWSAVF LNSLFNQEVQ IPLTESYCGP CPKNWICYKN NCYQFFDESK NWYESQASCM SQNASLLKVY SKEDQDLLKL VKSYHWMGLV HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT YICMQRTV|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Houchins J.P.,et al.J. Exp. Med. 173:1017-1020(1991).
Glienke J.,et al.Immunogenetics 48:163-173(1998).
Kothapalli R.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Shum B.P.,et al.J. Immunol. 168:240-252(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
If you have any additional inquiries please email technical services at firstname.lastname@example.org.