KLRK1, human recombinant protein
NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D
|Calculated MW||19.2 kDa (168 aa, 73-216 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSMIWSAVF LNSLFNQEVQ IPLTESYCGP CPKNWICYKN NCYQFFDESK NWYESQASCM SQNASLLKVY SKEDQDLLKL VKSYHWMGLV HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT YICMQRTV|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Houchins J.P.,et al.J. Exp. Med. 173:1017-1020(1991).
Glienke J.,et al.Immunogenetics 48:163-173(1998).
Kothapalli R.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Shum B.P.,et al.J. Immunol. 168:240-252(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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