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Aldose Reductase, human recombinant protein

Aldo-keto reductase family1, member B1, AKR1B1, ADR, ALDR1, ALR2, AR

     
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Product info
Primary Accession P15121
Concentration 1
Calculated MW 35.8 kDa (316 aa, 1-316 aa), confirmed by MALDI-TOF.
Additional Info
Gene ID 231
Gene Symbol AKR1B1
Other Names Aldo-keto reductase family1, member B1, AKR1B1, ADR, ALDR1, ALR2, AR
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA LLSCTSHKDY PFHEEF
Target/Specificity Aldose Reductase
Format Liquid
Storage -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
Citations (0)

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Background

Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily and catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Recombinant Aldose reductase (AKR1B) protein was expressed in E.coli and purified by using conventional chromatography techniques.

References

Bohren K.M.,et al.J. Biol. Chem. 264:9547-9551(1989).
Chung S.,et al.J. Biol. Chem. 264:14775-14777(1989).
Graham A.,et al.Nucleic Acids Res. 17:8368-8368(1989).
Grundmann U.,et al.DNA Cell Biol. 9:149-157(1990).
Nishimura C.,et al.J. Biol. Chem. 265:9788-9792(1990).

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$ 215.00
Cat# PBV10984r
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