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Aldose Reductase, human recombinant protein
Aldo-keto reductase family1, member B1, AKR1B1, ADR, ALDR1, ALR2, AR
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P15121 |
|---|---|
| Concentration | 1 |
| Calculated MW | 35.8 kDa (316 aa, 1-316 aa), confirmed by MALDI-TOF. |
| Gene ID | 231 |
|---|---|
| Gene Symbol | AKR1B1 |
| Other Names | Aldo-keto reductase family1, member B1, AKR1B1, ADR, ALDR1, ALR2, AR |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA LLSCTSHKDY PFHEEF |
| Target/Specificity | Aldose Reductase |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily and catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Recombinant Aldose reductase (AKR1B) protein was expressed in E.coli and purified by using conventional chromatography techniques.
References
Bohren K.M.,et al.J. Biol. Chem. 264:9547-9551(1989).
Chung S.,et al.J. Biol. Chem. 264:14775-14777(1989).
Graham A.,et al.Nucleic Acids Res. 17:8368-8368(1989).
Grundmann U.,et al.DNA Cell Biol. 9:149-157(1990).
Nishimura C.,et al.J. Biol. Chem. 265:9788-9792(1990).
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