|Calculated MW||This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 32.1 kDa. The predicted N-terminus is Leu 23. DTT-reduced Protein migrates as 44-48 kDa due to glycosylation.|
|Other Names||uPAR, PLAUR, CD87, MO3|
|Results||Measured by its binding ability in a functional ELISA. Immobilized human uPAR at 5 µg/ml (100 µl/well) can bind biotinylated human UPA with a linear range of 25 - 500 ng/ml.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.|
|Storage||-20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.|
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Provided below are standard protocols that you may find useful for product applications.
Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR act as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.
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Min H.Y.,et al.J. Immunol. 148:3636-3642(1992).
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Pyke C.,et al.FEBS Lett. 326:69-74(1993).
Casey J.R.,et al.Blood 84:1151-1156(1994).
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