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>   home   >   Products   >   Proteins   >   Human CellExp CD304 / NRP1 / Neurophilin-1, human recombinant protein   

Human CellExp CD304 / NRP1 / Neurophilin-1, human recombinant protein

NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Product info
Primary Accession O14786
Calculated MW This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 70.7 kDa. The predicted N-terminus is Phe 22. DTT-reduced Protein migrates as 85-90 kDa due to glycosylation.
Additional Info
Gene ID 8829
Gene Symbol NRP1
Other Names NRP1, Neuropilin-1, NRP, VEGF165R, CD304
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its binding ability in a functional ELISA. Immobilized rh NRP1 / Neuropilin‑1 / CD304 can bind rhVEGF165 with an apparent Kd < 1 nM.
Target/Specificity CD304/NRP1/Neurophilin-1
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Neuropilin-1 (NRP1) is also known as vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.


He Z.,et al.Cell 90:739-751(1997).
Soker S.,et al.Cell 92:735-745(1998).
Gagnon M.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:2573-2578(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 185.00
Cat# PBV10998r
(40 western blots)
Availability: 5-7days
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