|Calculated MW||This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.6 kDa. The predicted N-terminus is Lys 22. DTT-reduced Protein migrates as 35-45 kDa due to glycosylation.|
|Other Names||CD84, SLAMF5, LY9B, SLAMF5, hCD84, mCD84|
|Results||Measured in a cell proliferation assay using PHA stimulated human T cells in the presence of anti-CD3. The ED50 for this effect is typically 2-6 µg/ml in the presence of anti-CD3 immobilized at 20 ng/ml.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.|
|Storage||-20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.|
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Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contain one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.
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Krause S.W.,et al.Biochem. J. 346:729-736(2000).
Palou E.,et al.Tissue Antigens 55:118-127(2000).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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