|Calculated MW||This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 15.6 kDa. The predicted N-terminus is Ile 27. DTT-reduced Protein migrates as 22-28 kDa due to glycosylation.|
|Other Names||CD160, BY55, NK1, NK28|
|Results||Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse HVEM Fc Chimera at 1 µg/ml, the concentration of rhCD160 that produces 50% of the optimal binding response is approximately 1.0‑16 ng/ml.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.|
|Storage||-20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.|
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Provided below are standard protocols that you may find useful for product applications.
CD160 antigen also known as natural killer cell receptor BY55, is a 27 kDa glycoprotein, contains 1 Ig-like V-type (immunoglobulin-like) domain. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and non-classical MHC class I molecules. When expressed on vascular endothelial cells, CD160 propagates anti-angiogenic signals and promotes apoptosis.
Anumanthan A.,et al.J. Immunol. 161:2780-2790(1998).
Agrawal S.,et al.J. Immunol. 162:1223-1226(1999).
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