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>   home   >   Products   >   Proteins   >   Human CellExp CD74/DHLAG, human recombinant protein   

Human CellExp CD74/DHLAG, human recombinant protein


Product info
Primary Accession P04233
Calculated MW This protein is fused with 6×His tag at the N-terminus, has a calculated MW of 19.3 kDa. The predicted N-terminus is Gln 73. DTT-reduced Protein migrates as 23-33 kDa due to glycosylation.
Additional Info
Gene ID 972
Gene Symbol CD74
Other Names CD74, DHLAG, HLADG, II, Ia-GAMMA, p33, CLIP, INVG34
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5 µg/ml (100 µl/well) can bind biotinylated human CTSL1 with a linear range of 3.2 - 500 ng/ml.
Target/Specificity CD74/DHLAG
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Cluster of Differentiation 74 (CD74) also known as HLA class II histocompatibility antigen gamma chain (HLADG), is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.


Claesson L.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983).
Strubin M.,et al.EMBO J. 3:869-872(1984).
Kudo J.,et al.Nucleic Acids Res. 13:8827-8841(1985).
O'Sullivan D.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

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$ 195.00
$ 595.00
Cat# PBV11010r
(40 western blots)
Availability: 5-7days
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