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>   home   >   Products   >   Proteins   >   Human CellExp CD30 /TNFRSF8, human recombinant protein   

Human CellExp CD30 /TNFRSF8, human recombinant protein

TNFRSF8, CD30, D1S166E, Ki-1

Product info
Primary Accession P28908
Calculated MW This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 39.3 kDa. The predicted N-terminus is Phe 19. DTT-reduced Protein migrates as 75-90 kDa due to glycosylation.
Additional Info
Gene ID 943
Gene Symbol TNFRSF8
Other Names TNFRSF8, CD30, D1S166E, Ki-1
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its ability to block CD30 Ligand-induced IL-6 secretion by HDLM human Hodgkin’s lymphoma cells. The ED50 for this effect is typically 0.5 - 2.5 µg/ml in the presence of 50 ng/ml of Recombinant Human CD30 Ligand.
Target/Specificity CD30 /TNFRSF8
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Human CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.


Duerkop H.,et al.Cell 68:421-427(1992).
Jung W.,et al.Mol. Immunol. 31:1329-1334(1994).
Horie R.,et al.Blood 88:2422-2432(1996).
Durkop H.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 175.00
$ 575.00
Cat# PBV11012r
(40 western blots)
Availability: 5-7days
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