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>   home   >   Products   >   Proteins   >   Human CellExp ErbB2 / HER2 / CD340, human recombinant protein   

Human CellExp ErbB2 / HER2 / CD340, human recombinant protein

ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1

Product info
Primary Accession P04626
Calculated MW This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 72.4 kDa. The predicted N-terminus is Thr 23. DTT-reduced Protein migrates as 90-110 kDa due to glycosylation.
Additional Info
Gene ID 2064
Gene Symbol ErbB2
Other Names ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. The ED50 for this effect is typically 5-45 ng/ml in the presence of 0.6 µg/ml goat anti-hErbB2.
Target/Specificity ErbB2
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.


Yamamoto T.,et al.Nature 319:230-234(1986).
Coussens L.,et al.Science 230:1132-1139(1985).
Wakamatsu A.,et al.Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tal M.,et al.Mol. Cell. Biol. 7:2597-2601(1987).

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$ 175.00
$ 575.00
Cat# PBV11020r
(40 western blots)
Availability: 5-7days
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