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>   home   >   Products   >   Proteins   >   Human CellExp VEGFR2/Flk-1/KDR, human recombinant protein   

Human CellExp VEGFR2/Flk-1/KDR, human recombinant protein

KDR, CD309, FLK1, VEGFR, VEGFR2, kinase insert domain receptor

Product info
Primary Accession P35968
Calculated MW This protein with 6×his tag at C-terminus, and has a calculated MW of 84.1 kDa. DTT-reduced protein migrates as 100-110 kDa protein due to glycosylation.
Additional Info
Gene ID 3791
Gene Symbol VEGFR2
Other Names KDR, CD309, FLK1, VEGFR, VEGFR2, kinase insert domain receptor
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its ability to inhibit the VEGF dependent proliferation of HUVEC human umbilical vein endothelial cells. The ED50 for this effect is typically 9-20 ng/ml in the presence of 5 ng/ml rhVEGF165.
Target/Specificity VEGFR2
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Kinase insert domain receptor (KDR) also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.


Jin P.,et al.Arthritis Res. Ther. 10:R73-R73(2008).
Albuquerque R.J.,et al.Nat. Med. 15:1023-1030(2009).
Yin L.Y.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
Yu Y.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 165.00
$ 555.00
Cat# PBV11022r
(40 western blots)
Availability: 5-7days
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