Human CellExp FGFR1/CD331, human recombinant protein
FGFR1, FGFR-1, BFGFR, CD331, CEK, FGFBR, FLG, HBGFR, N-SAM, FLT2, H2, KAL2, FLJ14326, Fibroblast Gro
|Calculated MW||This protein is fused with 6×his tag at the C-terminus and has a calculated MW of 40.1 kDa. The predicted N-terminus is Arg 22. DTT-reduced SDS-PAGE, protein migrates as 60-65 kDa.|
|Other Names||FGFR1, FGFR-1, BFGFR, CD331, CEK, FGFBR, FLG, HBGFR, N-SAM, FLT2, H2, KAL2, FLJ14326, Fibroblast Growth Factor Receptor 1|
|Results||Measured by its ability to inhibit FGF-1 /FGF-acidic dependent proliferation of BALB /3T3 mouse fibroblasts. The ED50 for this effect is typically 15-50 ng/ml.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.|
|Storage||-20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.|
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Provided below are standard protocols that you may find useful for product applications.
Fibroblast growth factor receptor 1 (FGFR1) is also known as basic fibroblast growth factor receptor 1(BFGFR1), FMS-like tyrosine kinase, CD331, and is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is one of several fibroblast growth factor receptors, which are related proteins that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and embryonic development. The FGFR1 protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning allows the FGFR1 protein to interact with specific growth factors outside the cell and to receive signals that help the cell respond to its environment. When growth factors attach to the FGFR1 protein, the receptor triggers a cascade of chemical reactions inside the cell that instruct the cell to undergo certain changes, such as maturing to take on specialized functions. The FGFR1 protein is thought to play an important role in the development of the nervous system. This protein may also help regulate the growth of long bones, such as the large bones in the arms and legs.
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Dionne C.A.,et al.EMBO J. 9:2685-2692(1990).
Johnson D.E.,et al.Mol. Cell. Biol. 10:4728-4736(1990).
Isacchi A.,et al.Nucleic Acids Res. 18:1906-1906(1990).
Wennstroem S.,et al.Growth Factors 4:197-208(1991).
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