Human CellExp IL17R /CD217, human recombinant protein
CD217, CDw217, IL-17RA, IL17R, CANDF5, hIL-17R
|Calculated MW||This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 34.3 kDa. The predicted N-terminus is Leu 33. DTT-reduced Protein migrates as 55-60 kDa due to glycosylation.|
|Other Names||CD217, CDw217, IL-17RA, IL17R, CANDF5, hIL-17R|
|Results||Measured by its ability to inhibit IL-17 induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.01-0.1 µg/mL in the presence of 10 ng/mL recombinant human IL-17.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.|
|Storage||-20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Interleukin 17 receptor A (IL17RA), also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. IL 17RA associates with IL 17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
Yao Z.,et al.Cytokine 9:794-800(1997).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.