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>   home   >   Products   >   Proteins   >   Human CellExp CNTN2/Contactin-2, human recombinant protein   

Human CellExp CNTN2/Contactin-2, human recombinant protein

CNTN2, CNTN-2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAG1, TAX, TAX1, TAX-1, Cont

Product info
Primary Accession Q02246
Calculated MW This protein is fused with 6×his tag at the C-terminus and has a calculated MW of 109 kDa expressed. The predicted N-terminus is Ser 31. Protein migrates as 140 kDa in reduced SDS-PAGE resulting from glycosylation.
Additional Info
Gene ID 6900
Gene Symbol CNTN2
Other Names CNTN2, CNTN-2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAG1, TAX, TAX1, TAX-1, Contactin-2
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Optimal neurite outgrowth was observed when neurons were plated on 96-well culture plates that had been precoated with 50 µl/well of the rhContactin2 solution at 8-30 µg/ml.
Target/Specificity CNTN2/Contactin-2
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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Contactin-2 also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.


Hasler T.H.,et al.Eur. J. Biochem. 211:329-339(1993).
Tsiotra C.P.,et al.Genomics 18:562-567(1993).
Kozlov S.V.,et al.Genomics 30:141-148(1995).
Gregory S.G.,et al.Nature 441:315-321(2006).
Tsiotra C.P.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.

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$ 175.00
$ 575.00
Cat# PBV11063r
(40 western blots)
Availability: 5-7days
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