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>   home   >   Products   >   Proteins   >   Human CellExp Fc gamma RIIIB /CD16b, human recombinant protein   

Human CellExp Fc gamma RIIIB /CD16b, human recombinant protein


Product info
Primary Accession O75015
Calculated MW This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 21.7 kDa. The predicted N-terminus is Gly 17. DTT-reduced Protein migrates as 38-50 kDa due to glycosylation.
Additional Info
Gene ID 2215
Gene Symbol FCGR3B
Other Names FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its ability to bind human IgG with an estimated KD < 150 nM.
Target/Specificity Fc gamma RIIIB /CD16b
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner. CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16B also known as FCGR3B and FCG3B, is expressed specifically by polymorphonuclear leukocytes (neutrophils) and stimulated eosinophils. CD16B is the low affinity receptor for the Fc region of immunoglobulins gamma. FCGR3B binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, FCG3B is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. CD16B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.


Ravetch J.V.,et al.J. Exp. Med. 170:481-497(1989).
Simmons D.,et al.Nature 333:568-570(1988).
Simmons D.,et al.Nature 340:662-662(1989).
Peltz G.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:1013-1017(1989).
Scallon B.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5079-5083(1989).

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$ 175.00
$ 575.00
Cat# PBV11067r
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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