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Human CellExp FOLR1, human recombinant protein

FOLR1, FBP, FOLR, FOLR-1, Folate-receptor-alpha

Product info
Primary Accession P15328
Calculated MW This protein is fused with 6×his tag at the C-terminus and has a calculated MW of 25.4 kDa expressed. The predicted N-terminus is Arg 25. Protein migrates as 33-37 kDa in reduced SDS-PAGE resulting from glycosylation.
Additional Info
Gene ID 2348
Gene Symbol FOLR1
Other Names FOLR1, FBP, FOLR, FOLR-1, Folate-receptor-alpha
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its binding ability in a functional ELISA. When Folic Acid Bovine Serum Albumin is coated at 5 µg/ml (100 µl/well), the concentration of rhFOLR1 that produces 50% of the optimal binding response is found to be approximately 0.35-1.8 nM.
Target/Specificity FOLR1
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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Folate Receptor 1 (FOLR1) also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.


Elwood P.C.,et al.J. Biol. Chem. 264:14893-14901(1989).
Lacey S.W.,et al.J. Clin. Invest. 84:715-720(1989).
Campbell I.G.,et al.Cancer Res. 51:5329-5338(1991).
Coney L.R.,et al.Cancer Res. 51:6125-6132(1991).
Sadasivan E.,et al.Biochim. Biophys. Acta 1131:91-94(1992).

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$ 175.00
$ 575.00
Cat# PBV11077r
(40 western blots)
Availability: 5-7days
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