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>   home   >   Products   >   Proteins   >   Human CellExp SFRP1/SARP2, human recombinant protein   

Human CellExp SFRP1/SARP2, human recombinant protein


Product info
Primary Accession Q8N474
Calculated MW This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 33.4 kDa. The predicted N-terminus is Ser 32. DTT-reduced Protein migrates as 38 kDa due to glycosylation.
Additional Info
Gene ID 6422
Gene Symbol SFRP1
Other Names SFRP1, FRP, FRP1, SARP2, FrzA
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥92%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is typically 2.5 - 10 µg/ml.
Target/Specificity SFRP1/SARP2
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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Secreted frizzled-related protein 1 (SFRP1) also known as Secreted apoptosis-related protein 2 (SARP2), FRP, FRP1, is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1, SFRP2, SFRP3, SFRP4, SFRP5) that act as extracellular signaling ligands. SFRP1 / SARP-2 is widely expressed and absent from lung, liver and peripheral blood leukocytes, and with the highest levels in heart and fetal kidney. SARP2 / SFRP-1 is a 35 kDa prototypical member of the SFRP family. SARP2 / FRP-1 acts as a biphasic modulator of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations.


Finch P.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:6770-6775(1997).
Melkonyan H.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:13636-13641(1997).
Zhou Z.,et al.Int. J. Cancer 78:95-99(1998).
Chong J.M.,et al.J. Biol. Chem. 277:5134-5144(2002).
Bafico A.,et al.J. Biol. Chem. 274:16180-16187(1999).

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$ 185.00
Cat# PBV11079r
(40 western blots)
Availability: 5-7days
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