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>   home   >   Products   >   Proteins   >   Human CellExp GHR /Growth Hormone Receptor, human recombinant protein   

Human CellExp GHR /Growth Hormone Receptor, human recombinant protein

GHR, GHBP, GH receptor

Product info
Primary Accession P10912 
Calculated MW This protein is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 28.5 kDa. The predicted N-terminus is Ala 27. DTT-reduced Protein migrates as 40-50 kDa in SDS-PAGE due to glycosylation.
Additional Info
Gene ID 2690
Gene Symbol GHR
Other Names GHR, GHBP, GH receptor
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results The bioactivity is measured by its binding ability to human GH in a SPR assay. Covalently immobilized Recombinant Human GHR Protein can bind human growth hormone protein with affinity constant of 1.28 ±0.16 nM range.
Target/Specificity GHR /Growth Hormone Receptor
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
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Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

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$ 185.00
Cat# PBV11098r
(40 western blots)
Availability: 5-7days
Bulk Size
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