Human CellExp ICAM2 /CD102, human recombinant protein
ICAM2, CD102, Intercellular adhesion molecule 2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P13598 |
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Calculated MW | This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.3 kDa. The predicted N-terminus is Ser 22. DTT-reduced Protein migrates as 40-63 kDa due to glycosylation. |
Gene ID | 3384 |
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Gene Symbol | ICAM2 |
Other Names | ICAM2, CD102, Intercellular adhesion molecule 2 |
Gene Source | Human |
Source | HEK293 cells |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Target/Specificity | ICAM2 /CD102 |
Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
Format | Lyophilized |
Storage | -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Intercellular adhesion molecule 2 (ICAM2) is also known as CD antigen CD102, which belongs to the immunoglobulin superfamily and ICAM family. ICAM2 contains two Ig-like C2-type (immunoglobulin-like) domains. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 / CD102 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response; NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
References
Staunton D.E.,et al.Nature 339:61-64(1989).
Garcia-Aguilar J.,et al.Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases.
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
Wollscheid B.,et al.Nat. Biotechnol. 27:378-386(2009).
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