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Human CellExp IL-21, human recombinant protein

Human IL-21, Interleukin-21 Protein

Product info
Primary Accession Q9HBE4
Calculated MW This protein contains no "tag", has a calculated MW of 15.6 kDa. The predicted N-terminus is Gln 23. DTT-reduced Protein migrates as 20 kDa due to glycosylation.
Additional Info
Gene ID 59067
Gene Symbol IL21
Other Names Human IL-21, Interleukin-21 Protein
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥92%
Assay2&Purity2 N/A;
Recombinant Yes
Results The bio-activity was determined by its ability to induce IFN-γ production by NK-92 cells. The ED50 < 3 ng/ml, corresponding to a specific activity of >3X105 Unit/mg.
Target/Specificity IL-21
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.


Parrish-Novak J.,et al.Nature 408:57-63(2000).
Rahman M.,et al.FEBS Lett. 581:4001-4009(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Strengell M.,et al.J. Leukoc. Biol. 76:416-422(2004).
Sivakumar P.V.,et al.Immunology 112:177-182(2004).

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$ 215.00
$ 695.00
Cat# PBV11109r
(40 western blots)
Availability: 5-7days
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