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Human CellExp HAVCR1 / KIM1 / TIM1, human recombinant protein
HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, Hepatitis A virus cellular rec
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96D42 |
|---|---|
| Calculated MW | This protein contains a poly histidine tag at C-terminus and has a calculated MW of 31.3 kDa after removal of signal peptide. In DTT-reduced SDS-PAGE, rhHAVCR1 protein migrates as 80-100 kDa poly peptide due to high glycosylation. |
| Gene ID | 26762 |
|---|---|
| Gene Symbol | HAVCR1 |
| Other Names | HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, Hepatitis A virus cellular receptor 1 |
| Gene Source | Human |
| Source | HEK293 cells |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | Measured by its ability to inhibit anti-CD3 induced proliferation of stimulated human T cells. Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with 500 ng/ml anti-CD3 and rhTIM1. The ED50 for this effect is typically 0.15-1.0 µg/ml. |
| Target/Specificity | HAVCR1 / KIM1 / TIM1 |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hepatitis A virus cellular receptor 1 also known as HAVCR1, HAVCR, KIM1, TIM, TIM1, TIMD1, is widely expressed with highest levels in kidney and testis. The protein encoded by HAVCR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. HAVCR1 may play a role in T-helper cell development, the regulation of asthma and allergic diseases and in kidney injury and repair. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.
References
Feigelstock D.,et al.J. Virol. 72:6621-6628(1998).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Tami C.,et al.J. Virol. 81:3437-3446(2007).
van Timmeren M.M.,et al.J. Pathol. 212:209-217(2007).
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