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>   home   >   Products   >   Proteins   >   Human CellExp Osteoactivin / GPNMB, human recombinant protein   

Human CellExp Osteoactivin / GPNMB, human recombinant protein

GPNMB, HGFIN, NMB, Osteoactivin

Product info
Primary Accession Q96F58
Calculated MW This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 52.9 kDa. The predicted N-terminus is Ala 22. DTT-reduced Protein migrates as 85-100 kDa due to glycosylation.
Additional Info
Gene ID 10457
Gene Symbol GPNMB
Other Names GPNMB, HGFIN, NMB, Osteoactivin
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results ED50 for this effect is typically 4 - 16 µg/ml
Target/Specificity Osteoactivin / GPNMB
Application Notes Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

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$ 175.00
Cat# PBV11132r
(40 western blots)
Availability: 5-7days
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