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>   home   >   Products   >   Proteins   >   Human CellExp Osteoprotegerin / TNFRSF11B, human recombinant protein   

Human CellExp Osteoprotegerin / TNFRSF11B, human recombinant protein

TNFRSF11B, OCIF, OPG, Osteoprotegerin

Product info
Primary Accession O00300
Calculated MW This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 44.4 kDa. The predicted N-terminus is Glu 22. DTT-reduced Protein migrates as 55 kDa due to glycosylation.
Additional Info
Gene ID 4982
Gene Symbol TNFRSF11B
Other Names TNFRSF11B, OCIF, OPG, Osteoprotegerin
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity Osteoprotegerin / TNFRSF11B
Application Notes Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Citations (0)

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Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.


Simonet W.S.,et al.Cell 89:309-319(1997).
Yasuda H.,et al.Endocrinology 139:1329-1337(1998).
Morinaga T.,et al.Eur. J. Biochem. 254:685-691(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 145.00
Cat# PBV11133r
(40 western blots)
Availability: 5-7days
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