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Active Caspase-1, rat recombinant protein

Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.

Product info
Primary Accession P43527
Calculated MW ~ 34.6 KDa
Additional Info
Gene Symbol Casp1
Other Names Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.
Gene Source Rat
Source E. coli
Assay&Purity N/A;
Assay2&Purity2 N/A;
Recombinant Yes
Results >3000 units/mg
Target/Specificity Caspase-1
Application Notes Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Format Semi-Dry
Storage -80°C; Semi-Dry
Citations (0)

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Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284 amino acids with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques.


Keane K.M.,et al.Cytokine 7:105-110(1995).
Flaws J.A.,et al.Endocrinology 136:5042-5053(1995).

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$ 265.00
$ 465.00
Cat# PBV11136r
(40 western blots)
Availability: 5-7days
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