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Procathepsin S, human recombinant protein


Product info
Primary Accession P25774
Calculated MW 38.1 kDa (17-331 aa + N-terminal poly-his tag)
Additional Info
Gene ID 1520
Gene Symbol CTSS
Other Names CTSS
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results >1000 mU/mg (1 U = Digestion of 1 µmole/min) of Ac-VVR-AFC substrate (K144-100) after full activation.
Target/Specificity Procathepsin S
Application Notes Reconstitute in 25 mM Na2HPO4, 500 mM NaCl (pH 7.0) to 0.5-1 mg/ml
Format Lyophilized
Storage -80°C; Lyophilized from proprietary buffer.
Citations (0)

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Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.


Shi G.-P.,et al.J. Biol. Chem. 267:7258-7262(1992).
Wiederanders B.,et al.J. Biol. Chem. 267:13708-13713(1992).
Wiederanders B.,et al.Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
Shi G.-P.,et al.J. Biol. Chem. 269:11530-11536(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 225.00
$ 795.00
$ 6,950.00
Cat# PBV11137r
(40 western blots)
Availability: 5-7days
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