|Calculated MW||~85.0 kDa. The extracellular domain of mouse Notch-1 (aa 19-488) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.|
|Other Names||Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300|
|Application Notes||Reconstitute with sterile water to 1 mg/ml.|
|Storage||-20°C; Lyophilized with PBS|
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Provided below are standard protocols that you may find useful for product applications.
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
Franco del Amo F.,et al.Genomics 15:259-264(1993).
Nye J.S.,et al.Development 120:2421-2430(1994).
Foltz D.R.,et al.Curr. Biol. 12:1006-1011(2002).
Tsuji H.,et al.Carcinogenesis 24:1257-1268(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
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