Notch-1, mouse recombinant protein
Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01705 |
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Calculated MW | ~85.0 kDa. The extracellular domain of mouse Notch-1 (aa 19-488) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1. |
Gene ID | 18128 |
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Gene Symbol | NOTCH1 |
Other Names | Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300 |
Gene Source | Mouse |
Source | CHO cells |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Target/Specificity | Notch-1 |
Application Notes | Reconstitute with sterile water to 1 mg/ml. |
Format | Lyophilized |
Storage | -20°C; Lyophilized with PBS |
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Provided below are standard protocols that you may find useful for product applications.
Background
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
References
Franco del Amo F.,et al.Genomics 15:259-264(1993).
Nye J.S.,et al.Development 120:2421-2430(1994).
Foltz D.R.,et al.Curr. Biol. 12:1006-1011(2002).
Tsuji H.,et al.Carcinogenesis 24:1257-1268(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
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