|Calculated MW||~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.|
|Other Names||Neurogenic Locus Notch Homolog Protein 2; Notch B|
|Application Notes||Reconstitute with sterile water to 1 mg/ml.|
|Storage||-20°C; Lyophilized with PBS|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
Hamada Y.,et al.Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
Lardelli M.,et al.Exp. Cell Res. 204:364-372(1993).
Milner L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:13014-13019(1996).
Hamada Y.,et al.Development 126:3415-3424(1999).
Higuchi M.,et al.Brain Res. Mol. Brain Res. 29:263-272(1995).
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