|Calculated MW||~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.|
|Other Names||Neurogenic Locus Notch Homolog Protein 2; Notch B|
|Application Notes||Reconstitute with sterile water to 1 mg/ml.|
|Storage||-20°C; Lyophilized with PBS|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
Hamada Y.,et al.Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
Lardelli M.,et al.Exp. Cell Res. 204:364-372(1993).
Milner L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:13014-13019(1996).
Hamada Y.,et al.Development 126:3415-3424(1999).
Higuchi M.,et al.Brain Res. Mol. Brain Res. 29:263-272(1995).
If you have any additional inquiries please email technical services at firstname.lastname@example.org.