|Calculated MW||159 kDa (N-terminal GST tag)|
|Other Names||KIAA0901, JM21, HD6|
|Results||560 pmole/min/ µg.|
|Storage||-80°C; In 50 mM Tris-HCl, pH 8.0, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 10% glycerol, and 2 mM DTT.|
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Provided below are standard protocols that you may find useful for product applications.
HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.
Grozinger C.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4868-4873(1999).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Ohara O.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Strom T.M.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
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