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HDAC6, human recombinant protein

KIAA0901, JM21, HD6

Product info
Primary Accession Q9UBN7
Calculated MW 159 kDa (N-terminal GST tag)
Additional Info
Gene ID 10013
Gene Symbol HDAC6
Other Names KIAA0901, JM21, HD6
Gene Source Human
Source Baculovirus
Assay&Purity SDS-PAGE; ≥82%
Assay2&Purity2 N/A;
Recombinant Yes
Results 560 pmole/min/ µg.
Target/Specificity HDAC6
Format Liquid
Storage -80°C; In 50 mM Tris-HCl, pH 8.0, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 10% glycerol, and 2 mM DTT.
Citations (0)

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HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.


Grozinger C.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4868-4873(1999).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Ohara O.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Strom T.M.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 255.00
Cat# PBV11144r
(40 western blots)
Availability: 5-7days
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