Haptoglobin, (Phenotype 1-1) Human Plasma recombinant protein
Hp 1-1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P00738 |
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Calculated MW | 86 kDa |
Gene ID | 3240 |
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Gene Symbol | HP |
Other Names | Hp 1-1 |
Gene Source | Human |
Source | Human Plasma |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | No |
Target/Specificity | Haptoglobin |
Format | Lyophilized |
Storage | -20°C; Lyophilized as a salt-free solid. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Of the three haptoglobin phenotypes, Hp 1-1 is the most effective in binding free hemoglobin and in suppressing the inflammatory responses associated with free hemoglobin. Hp 1-1 protects against vascular complications in diabetes, is associated with sickle cell anemia, and is more common than other phenotypes in cases of cirrhosis. Individuals who are phenotype 1-1 have the highest concentration of haptoglobin in plasma.
References
van der Straten A.,et al.EMBO J. 2:1003-1007(1983).
Yang F.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:5875-5879(1983).
van der Straten A.,et al.FEBS Lett. 168:103-107(1984).
Brune J.L.,et al.Nucleic Acids Res. 12:4531-4538(1984).
Bensi G.,et al.EMBO J. 4:119-126(1985).
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