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FTO, human recombinant protein
Fat Mass and Obesity-associated Protein; FATSO.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9C0B1 |
|---|---|
| Concentration | 0.2 |
| Calculated MW | ~65 kDa (SDS-PAGE). Human FTO (aa 2-505) is fused at the N-terminus to a His-tag. |
| Gene ID | 79068 |
|---|---|
| Gene Symbol | FTO |
| Other Names | Fat Mass and Obesity-associated Protein; FATSO. |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Target/Specificity | FTO |
| Format | Liquid |
| Storage | -20°C; 0.2 mg/ml of 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
References
Nagase T.,et al.DNA Res. 7:347-355(2000).
Martin J.,et al.Nature 432:988-994(2004).
Dina C.,et al.Nat. Genet. 39:724-726(2007).
Frayling T.M.,et al.Science 316:889-894(2007).
Jia G.,et al.FEBS Lett. 582:3313-3319(2008).
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