|Calculated MW||~65 kDa (SDS-PAGE). Human FTO (aa 2-505) is fused at the N-terminus to a His-tag.|
|Other Names||Fat Mass and Obesity-associated Protein; FATSO.|
|Storage||-20°C; 0.2 mg/ml of 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
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Jia G.,et al.FEBS Lett. 582:3313-3319(2008).
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