|Calculated MW||~65 kDa (SDS-PAGE). Human FTO (aa 2-505) is fused at the N-terminus to a His-tag.|
|Other Names||Fat Mass and Obesity-associated Protein; FATSO.|
|Storage||-20°C; 0.2 mg/ml of 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
Nagase T.,et al.DNA Res. 7:347-355(2000).
Martin J.,et al.Nature 432:988-994(2004).
Dina C.,et al.Nat. Genet. 39:724-726(2007).
Frayling T.M.,et al.Science 316:889-894(2007).
Jia G.,et al.FEBS Lett. 582:3313-3319(2008).
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