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NAD Kinase (catalytic domain), human recombinant protein
NADK; Poly (P)/ATP NAD Kinase; EC 2.7.1.23.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95544 |
|---|---|
| Concentration | 1 |
| Calculated MW | ~42 kDa (monomer). Human NAD kinase (aa 64-446) is fused at the N-terminus to a His-tag. |
| Gene ID | 65220 |
|---|---|
| Gene Symbol | NADK |
| Other Names | NADK; Poly (P)/ATP NAD Kinase; EC 2.7.1.23. |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | ≥ 2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NADP per min. |
| Target/Specificity | NAD Kinase (catalytic domain) |
| Format | Liquid |
| Storage | -20°C; 1 mg/ml of ammonium sulphate suspension. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NAD kinase catalyzes the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which in its reduced form acts as an electron donor for biosynthetic reactions. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.
References
Lerner F.,et al.Biochem. Biophys. Res. Commun. 288:69-74(2001).
Xu X.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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