NMNAT1, human recombinant protein
Nicotinamide Mononucleotide Adenylyl-transferase 1, NMN Adenylyltransferase 1; NaMN Adenylyltransfer
|Calculated MW||~33.3 kDa (monomer). Human full-length NMNAT1 (aa 1-279) is fused at the N-terminus to a His-tag.|
|Other Names||Nicotinamide Mononucleotide Adenylyl-transferase 1, NMN Adenylyltransferase 1; NaMN Adenylyltransferase 1; EC 220.127.116.11.|
|Results||≥ 5U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min.|
|Storage||-20°C; 1 mg/ml in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 2 mM DTT and 10% glycerol.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It interacts with PARP-1/ARTD1. It protects against axonal degeneration following mechanical or toxic insults. It is widely expressed.
Schweiger M.,et al.FEBS Lett. 492:95-100(2001).
Emanuelli M.,et al.J. Biol. Chem. 276:406-412(2001).
Fernando F.S.,et al.Gene 284:23-29(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.