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NMNAT1, human recombinant protein
Nicotinamide Mononucleotide Adenylyl-transferase 1, NMN Adenylyltransferase 1; NaMN Adenylyltransfer
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HAN9 |
|---|---|
| Concentration | 1 |
| Calculated MW | ~33.3 kDa (monomer). Human full-length NMNAT1 (aa 1-279) is fused at the N-terminus to a His-tag. |
| Gene ID | 64802 |
|---|---|
| Gene Symbol | NMNAT1 |
| Other Names | Nicotinamide Mononucleotide Adenylyl-transferase 1, NMN Adenylyltransferase 1; NaMN Adenylyltransferase 1; EC 2.7.7.1. |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | ≥ 5U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min. |
| Target/Specificity | NMNAT1 |
| Format | Liquid |
| Storage | -20°C; 1 mg/ml in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 2 mM DTT and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It interacts with PARP-1/ARTD1. It protects against axonal degeneration following mechanical or toxic insults. It is widely expressed.
References
Schweiger M.,et al.FEBS Lett. 492:95-100(2001).
Emanuelli M.,et al.J. Biol. Chem. 276:406-412(2001).
Fernando F.S.,et al.Gene 284:23-29(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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