Human CellExp RBP4, human recombinant protein
Retinol Binding Protein 4, Plasma retinol-binding protein, PRBP, RBP
|Calculated MW||~23.0 kDa (monomer). Human RBP4 (aa 19-201) is fused at the N-terminus to a FLAG®-tag.|
|Other Names||Retinol Binding Protein 4, Plasma retinol-binding protein, PRBP, RBP|
|Storage||-20°C; 0.5 mg/ml of 0.2 µm-filtered solution in PBS, pH 7.2.|
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Retinol binding protein 4 (RBP4; RBP) is a 21 kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.
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Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
D'Onofrio C.,et al.EMBO J. 4:1981-1989(1985).
Rask L.,et al.Ups. J. Med. Sci. 92:115-146(1987).
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